The origin of Iron Man, leading to the deaths of Wong-Chu and Professor Yinsen, and how Tony Stark escaped Viet Nam with the help of soldier James Rhodes, and how the experience forged a long friendship with the two.

The Human Torch's solo adventure into the 5th Dimension where he battled the tyrant Zemu, and freed the people who lived there.

Ant Man's first encounter with his long time foe Egghead.

Thor's adventure into the Soviet Union to save captured scientists, an episode that was complicated due to the interference of Loki.

Rick Jones using a Gamma device to change Bruce Banner's mutation into the Hulk, for the first time Banner is able to utilize his Hulk body with the intelligence of Bruce Banner.

The first time the Fantastic Four experience financial problems.

And ending on a similar note, Spider-Man's first adventure in which he tries to rescue John Jameson's space capsule from destruction, despite the bad press from Jameson's father, editor of the Daily Bugle, J. Jonah Jameson.