Virginia Cleo Andrews (born Cleo Virginia Andrews) was born June 6, 1923 in Portsmouth, Virginia. The youngest child and the only daughter of William Henry Andrews, a career navy man who opened a tool-and-die business after retirement, and Lillian Lenora Parker Andrews, a telephone operator.

She spent her happy childhood years in Portsmouth, Virginia, living briefly in Rochester, New York. The Andrews family returned to Portsmouth while Virginia was in high school.

While a teenager, Virginia suffered a tragic accident, falling down the stairs at her school and incurred severe back injuries.

Arthritis and a failed spinal surgical procedure forced her to spend most of her life on crutches or in a wheelchair.

Virginia excelled in school and, at fifteen, won a scholarship for writing a parody of Tennyson's Idylls of the King.

She proudly earned her diploma from Woodrow Wilson High School in Portsmouth. After graduation, she nurtured her artistic talent by completing a four-year correspondence art course while living at home with her family.

After William Andrews died in the late 1960s, Virginia helped to support herself and her mother through her extremely successful career as a commercial artist, portrait painter, and fashion illustrator.

Frustrated with the lack of creative satisfaction that her work provided, Virginia sought creative release through writing, which she did in secret.

In 1972, she completed her first novel, The Gods of the Green Mountain [sic], a science-fantasy story. It was never published.

Between 1972 and 1979, she wrote nine novels and twenty short stories, of which only one was published.

"I Slept with My Uncle on My Wedding Night", a short fiction piece, was published in a pulp confession magazine.

Promise gleamed over the horizon for Virginia when she submitted a 290,000-word novel, The Obsessed, to a publishing company.

She was told that the story had potential, but needed to be trimmed and spiced up a bit. She drafted a new outline in a single night and added "unspeakable things my mother didn't want me to write about."

 The ninety-eight-page revision was re-titled Flowers in the Attic and she was paid a $7,500 advance. Her new-generation Gothic novel reached the bestseller lists a mere two weeks after its 1979 paperback publication by Pocket Books.

Petals on the Wind, her sequel to Flowers, was published the next year, earning Virginia a $35,000 advance.

The second book remained on the New York Times bestseller list for an unbelievable nineteen weeks (Flowers also returned to the list).

These first two novels alone sold over seven million copies in only two years. The third novel of the Colanguage series, If There Be Thorns, was released in 1981, bringing Virginia a $75,000 advance. It reached No. 2 on many bestseller lists within its first two weeks.

Taking a break from the chronicles of Chris and Cathy Colanguage, Virginia published her one, and only, stand-alone novel, My Sweet Audrina, in 1982.

The book welcomed an immediate success, topping the sales figures of her previous novels. Two years later, a fourth Colanguage novel was released, Seeds of Yesterday.

According to the New York Times, Seeds was the best-selling fiction paperback novel of 1984. Also in 1984, V.C. Andrews was named "Professional Woman of the Year" by the city of Norfolk, Virginia.

Upon Andrews's death in 1986, two final novels—Garden of Shadows and Fallen Hearts—were published.

These two novels are considered the last to bear the "V.C. Andrews" name and to be almost completely written by