Private Life vs. Public Image: The book explores the dichotomy between John F. Kennedy's public image as a charismatic and inspiring leader and his private life, which included various personal indiscretions.

Alleged Affairs and Womanizing: Hersh delves into allegations and evidence of Kennedy's numerous extramarital affairs, shedding light on aspects of his personal life that were not widely known during his presidency.

Mob Connections and Influence: The book suggests connections between Kennedy and organized crime figures, exploring potential ties and influences that may have existed during his political career.

Medical Issues and Medication: Hersh discusses Kennedy's health issues and the medications he took, shedding light on how these factors may have affected his decision-making and leadership.

Political Machinations: The book explores various political strategies and machinations employed by Kennedy, including behind-the-scenes maneuvering and decisions that may have been obscured from the public eye.

Crisis Management: Hersh examines Kennedy's handling of crises, both domestic and international, and assesses whether his personal life had any impact on his decision-making during critical moments.

Intelligence Community Critique: The book presents a critical view of Kennedy's relationship with the intelligence community and questions the effectiveness of his decision-making in matters related to national security.

Vietnam War Decision-Making: Hersh analyzes Kennedy's decisions regarding U.S. involvement in the Vietnam War, exploring the factors that influenced his policies and actions.

Assassination Conspiracies: While the book primarily focuses on Kennedy's presidency, it may touch on some conspiracy theories related to his assassination in 1963.

Legacy and Impact: Hersh evaluates Kennedy's legacy in light of the revelations presented in the book, considering how the darker aspects of his personal and political life may have influenced his impact on American history.