On the Inside explores the reunion of four doctor friends, Anuja- the cardiothoracic anesthesiologist, Raghu- the intensivist, Sonali- the infertility specialist and Charles- the cardiac surgeon. After a hiatus of twenty- five years, Anuja decides to bring her friends together. While being apprehensive about their ability to rekindle the easy chemistry they shared in college, Anuja takes up the challenge and reaches out to them over the internet.

Unable to connect with each other across cities and continents; caught up chasing dreams, chasing away ghosts and trying to find themselves, the group has drifted apart. Each is a success story, different specialties, and different lifestyles.